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5-Bromo-1H-indazole-7-carboxylic acid

  • CAS No. 953409-99-9

  • Cat. No. CS-0038921
  • Purity≥96%
  • MDL No.MFCD13177019

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1H-indazole-7-carboxylic acid|CS-0038921

Structure of 953409-99-9

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General Information

  • CAS No. 953409-99-9
  • Cat. No. CS-0038921
  • Purity ≥96%
  • MDL No. MFCD13177019
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂O₂
  • Molecular Weight 241.04
  • Synonym(s) 5-Bromo-7-carboxy-1H-indazole
  • SMILES C1=C2C=NNC2=C(C=C1Br)C(=O)O

Description

5-Bromo-1H-indazole-7-carboxylic acid features a brominated indazole core with a carboxylic acid group at the 7-position, enabling direct conjugation in bioconjugation and medicinal chemistry. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, offering enhanced metabolic stability and tunable polarity for target-directed drug discovery.

Application

5-Bromo-1H-indazole-7-carboxylic acid serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. The bromo group enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid functionality facilitates amide formation, esterification, and direct derivatization. Its stability under standard reaction conditions and compatibility with diverse functional groups make it well-suited for iterative synthetic strategies in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   2.0236
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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