7-Bromo-5-chloro-1H-indole-2-carboxylic acid

Name: 7-Bromo-5-chloro-1H-indole-2-carboxylic acid
Brand: ChemScene
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CAS No. 952959-39-6
Cat. No. CS-0041232
Purity≥98%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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7-Bromo-5-chloro-1H-indole-2-carboxylic acid|CS-0041232

Structure of 952959-39-6

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Description

7-Bromo-5-chloro-1H-indole-2-carboxylic acid features a halogenated indole core with complementary bromo and chloro substituents at the 7- and 5-positions, respectively. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and bioactive molecule frameworks. The carboxylic acid group enables direct coupling reactions or derivatization under standard conditions. Bench-stable and moisture-tolerant, it serves as a robust building block for targeted synthesis in medicinal chemistry and materials science.

Application

7-Bromo-5-chloro-1H-indole-2-carboxylic acid serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling direct incorporation into bioactive scaffolds via standard coupling reactions. The molecule features orthogonal halogen handles (Br at C7, Cl at C5) that facilitate selective cross-coupling, while the carboxylic acid group supports amide formation and derivatization. Bench-stable and readily purified by recrystallization, it functions efficiently in Pd-catalyzed transformations and is compatible with common protecting group strategies in multi-step syntheses.

General Information

CAS No. 952959-39-6
Cat. No. CS-0041232
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₅BrClNO₂
Molecular Weight 274.50
Synonym(s) 7-Bromo-5-chloro-1h-indole-2-carboxylicacid
SMILES O=C(C(N1)=CC2=C1C(Br)=CC(Cl)=C2)O

Computational Chemistry Data

TPSA 53.09
LogP 3.282
H_Acceptors 1
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Key Words

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7-Bromo-5-chloro-1H-indole-2-carboxylic acid

CAS No. 952959-39-6

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