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CS-W001157 4
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4-Methyl-1H-indazol-7-amine

  • CAS No. 952183-44-7

  • Cat. No. CS-0036524
  • Purity≥98%
  • MDL No.MFCD09607935

*For research and further manufacturing use only, not for direct human use.

4-Methyl-1H-indazol-7-amine|CS-0036524

Structure of 952183-44-7

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General Information

  • CAS No. 952183-44-7
  • Cat. No. CS-0036524
  • Purity ≥98%
  • MDL No. MFCD09607935
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉N₃
  • Molecular Weight 147.18
  • Synonym(s) 7-Amino-4-methyl-1H-indazole
  • SMILES NC1=CC=C(C)C2=C1NN=C2

Description

4-Methyl-1H-indazol-7-amine features a fused bicyclic indazole core with a methyl group at the 4-position and a primary amine at the 7-position. This configuration imparts enhanced solubility and stability under standard bench conditions, enabling straightforward incorporation into medicinal chemistry campaigns. The electron-rich aromatic system supports efficient coupling reactions, facilitating rapid access to diverse heterocyclic scaffolds for drug discovery applications.

Application

4-Methyl-1H-indazol-7-amine serves as a versatile building block for medicinal chemistry and materials science, enabling efficient construction of bioactive heterocycles. Its electron-rich indazole core exhibits robust stability and favorable solubility, facilitating direct functionalization at the 7-amino position. The methyl group enhances metabolic stability and modulates electronic properties, while the amine functionality supports diverse coupling reactions—such as Suzuki-Miyaura, Buchwald-Hartwig, and reductive amination—enabling rapid diversification in drug discovery campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.45352
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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