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Structure of 951753-87-0
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5-Isothiocyanato-3-(trifluoromethyl)picolinonitrile features a reactive isothiocyanate group flanked by a trifluoromethyl and nitrile substituent on a picoline scaffold. This electron-deficient heterocycle enables selective conjugation with amine-functionalized biomolecules, offering enhanced stability and solubility in polar solvents. Ideal for bioconjugation and probe synthesis under standard bench conditions.
5-Isothiocyanato-3-(trifluoromethyl)picolinonitrile serves as a versatile building block for the synthesis of functionalized heterocycles and bioactive scaffolds. The isothiocyanate group enables efficient conjugation reactions with amines, facilitating the construction of thiourea-linked molecules under mild conditions. The trifluoromethyl and nitrile functionalities provide enhanced metabolic stability and electronic modulation, while the picoline core offers a rigid, planar framework suitable for medicinal chemistry applications. Bench-stable and compatible with standard purification techniques, it functions reliably in multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 2928
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Class : 6.1,8
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Packing Group : Ⅱ
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Hazard Statements : H301-H311-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P302+P352-P304+P340-P330-P361-P363-P405-P501
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Lot numbers can be found on the outside label of a product: