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CS-W001157 4
Total: USD 88.00

B-(2-Chloro-5-fluoro-4-pyridinyl)boronic acid

  • CAS No. 951677-47-7

  • Cat. No. CS-0040197
  • Purity≥98%
  • MDL No.MFCD04972404
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

B-(2-Chloro-5-fluoro-4-pyridinyl)boronic acid|CS-0040197

Structure of 951677-47-7

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Description

2-Chloro-5-fluoropyridine-4-boronic acid features a pyridine core bearing strategically positioned halogen and boronic acid functionalities. This combination enables direct coupling in Suzuki-Miyaura reactions without requiring prior functionalization. The electron-deficient heterocycle enhances reactivity, while the boronic acid group offers stability under standard handling conditions. Ideal for constructing complex fluorinated heterocycles in medicinal chemistry and materials science applications.

Application

2-Chloro-5-fluoropyridine-4-boronic acid serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of substituted pyridine scaffolds. Its ortho-halogen and boronic acid functionalities permit sequential functionalization, while the fluorine substituent enhances metabolic stability in medicinal chemistry applications. The compound exhibits good bench stability and is compatible with standard Suzuki-Miyaura coupling conditions, facilitating rapid access to complex heterocyclic architectures.

General Information

  • CAS No. 951677-47-7
  • Cat. No. CS-0040197
  • Purity ≥98%
  • MDL No. MFCD04972404
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BClFNO₂
  • Molecular Weight 175.35
  • Synonym(s) boronic acid, B-(2-chloro-5-fluoro-4-pyridinyl)-
  • SMILES FC1=CN=C(Cl)C=C1B(O)O

Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.4461
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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