Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2,6-Difluoro-3-hydroxybenzamide

  • CAS No. 951122-37-5

  • Cat. No. CS-0128009
  • Molecule weight173.12
  • Purity≥98%
  • MDL No.MFCD18824499

*For research and further manufacturing use only, not for direct human use.

2,6-Difluoro-3-hydroxybenzamide|CS-0128009

Structure of 951122-37-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 951122-37-5
  • Cat. No. CS-0128009
  • Purity ≥98%
  • MDL No. MFCD18824499
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₂
  • Molecular Weight 173.12
  • Synonym(s) None
  • SMILES O=C(N)C1=C(F)C=CC(O)=C1F

Description

2,6-Difluoro-3-hydroxybenzamide features a strategically positioned hydroxyl group flanked by two fluorine atoms, delivering enhanced electronic polarization and metabolic stability. This combination enables robust integration into bioactive scaffolds, particularly in kinase inhibitor design and peptide conjugation workflows. The molecule exhibits favorable solubility characteristics under standard conditions and demonstrates excellent bench-stability during synthesis and purification.

Application

2,6-Difluoro-3-hydroxybenzamide serves as a versatile building block for the synthesis of fluorinated aromatic scaffolds in medicinal chemistry. The ortho-difluoro substitution pattern enables directed metalation and facilitates subsequent cross-coupling reactions. The phenolic hydroxyl group offers a handle for derivatization or protection, while the amide functionality provides stability and polarity control. Its bench-stable nature and compatibility with common reaction conditions make it well-suited for iterative synthesis workflows.

Synthesis

  • Route1
    • null|null
      1256478-39-3
    • ~96%
    • In-stock
      2,6-Difluoro-3-hydroxybenzamide|CS-0128009
      951122-37-5

    References

    • Sorto, Nohemy A.; Olmstead, Marilyn M.; Shaw, Jared T. Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7946 - 7949
  • Route2
    • 2,6-Difluoro-3-(methoxymethoxy)benzoic acid|CS-0316628
      1190603-51-0
    • ~%
    • In-stock
      2,6-Difluoro-3-hydroxybenzamide|CS-0128009
      951122-37-5

    References

    • Ding, Zi-Chun; Zhou, Weicheng; Ma, Xiang Synlett, 2012 , vol. 23, # 7 p. 1039 - 1042
  • Route3
    • Ethyl 2,6-difluoro-3-(methoxymethoxy)benzoate|CS-1216043
      1384476-81-6
    • ~%
    • In-stock
      2,6-Difluoro-3-hydroxybenzamide|CS-0128009
      951122-37-5

    References

    • Ding, Zi-Chun; Zhou, Weicheng; Ma, Xiang Synlett, 2012 , vol. 23, # 7 p. 1039 - 1042

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.7693
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2,6-Difluoro-3-hydroxybenzamide sigma2,6-Difluoro-3-hydroxybenzamide manufacturer2,6-Difluoro-3-hydroxybenzamide price2,6-Difluoro-3-hydroxybenzamide structure2,6-Difluoro-3-hydroxybenzamide SDSbuy 2,6-Difluoro-3-hydroxybenzamide2,6-Difluoro-3-hydroxybenzamide supplier2,6-Difluoro-3-hydroxybenzamide uses2,6-Difluoro-3-hydroxybenzamide molecular weightprice of 2,6-Difluoro-3-hydroxybenzamide2,6-Difluoro-3-hydroxybenzamide chemical name formula of 2,6-Difluoro-3-hydroxybenzamide
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label