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Structure of 951122-37-5
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2,6-Difluoro-3-hydroxybenzamide features a strategically positioned hydroxyl group flanked by two fluorine atoms, delivering enhanced electronic polarization and metabolic stability. This combination enables robust integration into bioactive scaffolds, particularly in kinase inhibitor design and peptide conjugation workflows. The molecule exhibits favorable solubility characteristics under standard conditions and demonstrates excellent bench-stability during synthesis and purification.
2,6-Difluoro-3-hydroxybenzamide serves as a versatile building block for the synthesis of fluorinated aromatic scaffolds in medicinal chemistry. The ortho-difluoro substitution pattern enables directed metalation and facilitates subsequent cross-coupling reactions. The phenolic hydroxyl group offers a handle for derivatization or protection, while the amide functionality provides stability and polarity control. Its bench-stable nature and compatibility with common reaction conditions make it well-suited for iterative synthesis workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501
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Lot numbers can be found on the outside label of a product: