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CS-W001157 4
Total: USD 88.00

4-Chlorobenzene-1,2-diamine

  • CAS No. 95-83-0

  • Cat. No. CS-W007387
  • Purity≥97%
  • MDL No.MFCD00011691

*For research and further manufacturing use only, not for direct human use.

4-Chlorobenzene-1,2-diamine|CS-W007387

Structure of 95-83-0

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General Information

  • CAS No. 95-83-0
  • Cat. No. CS-W007387
  • Purity ≥97%
  • MDL No. MFCD00011691
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClN₂
  • Molecular Weight 142.59
  • Synonym(s) 4-Chloro-o-phenylenediamine
  • SMILES C1=C(Cl)C=CC(=C1N)N

Description

Undergoes cyclizations and cyclocondensations to form benzimidazoles.

Application

4-Chlorobenzene-1,2-diamine serves as a key building block in the synthesis of heterocyclic scaffolds and functionalized aromatic systems. Its ortho-diamine motif enables efficient cyclization reactions, including imine formation and metal-catalyzed coupling processes. The chlorine substituent provides a handle for further functionalization via nucleophilic substitution or transition-metal-catalyzed cross-coupling, enhancing versatility in medicinal chemistry and materials science applications. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for routine synthetic workflows.

Synthesis

  • Route1
    • null|null
      89-63-4
    • ~10%
    • In-stock
      4-Chlorobenzene-1,2-diamine|CS-W007387
      95-83-0

    References

    • Yu; Liu; Hu Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 919 - 924
  • Route2

    References

    • Cantillo, David; Moghaddam, Mojtaba Mirhosseini; Kappe, C. Oliver Journal of Organic Chemistry, 2013 , vol. 78, # 9 p. 4530 - 4542
  • Route3
    • null|null
      17348-69-5
    • ~88%
    • In-stock
      4-Chlorobenzene-1,2-diamine|CS-W007387
      95-83-0

    References

    • Borah, Harsha N.; Prajapati, Dipak; Boruah, Romesh C. Synthetic Communications, 2009 , vol. 39, # 2 p. 267 - 272

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335-H351
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.04
  • LogP   1.5044
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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