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(9H-Fluoren-9-yl)methyl 3-hydroxypyrrolidine-1-carboxylate

  • CAS No. 948551-28-8

  • Cat. No. CS-0526978
  • Molecule weight309.36
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(9H-Fluoren-9-yl)methyl 3-hydroxypyrrolidine-1-carboxylate|CS-0526978

Structure of 948551-28-8

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General Information

  • CAS No. 948551-28-8
  • Cat. No. CS-0526978
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₉NO₃
  • Molecular Weight 309.36
  • Synonym(s) None
  • SMILES O=C(N1CC(O)CC1)OCC2C3=C(C4=C2C=CC=C4)C=CC=C3

Description

This fluorenylmethoxycarbonyl-protected pyrrolidine derivative features a pendant hydroxyl group enabling selective derivatization. The 9-fluorenylmethyl (Fmoc) moiety provides robust protection with facile removal under mild basic conditions, while the hydroxypyrrolidine scaffold offers a versatile chiral building block for peptide and small-molecule synthesis.

Application

(9H-Fluoren-9-yl)methyl 3-hydroxypyrrolidine-1-carboxylate serves as a versatile protected amino acid building block, enabling efficient access to pyrrolidine-containing scaffolds in medicinal chemistry. The fluorenylmethoxycarbonyl (Fmoc) group provides excellent stability and orthogonal deprotection under mild basic conditions, while the C3 hydroxyl functionality offers a handle for selective derivatization or incorporation into complex molecular architectures. Its compatibility with standard peptide coupling protocols and ease of purification make it a practical choice for solid-phase synthesis and fragment-based drug discovery workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   3.0021
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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