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CS-W001157 4
Total: USD 88.00

4-Fluoro-3-methoxybenzeneacetic acid

  • CAS No. 946713-86-6

  • Cat. No. CS-0040355
  • Purity≥98%
  • MDL No.MFCD08146650

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-methoxybenzeneacetic acid|CS-0040355

Structure of 946713-86-6

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General Information

  • CAS No. 946713-86-6
  • Cat. No. CS-0040355
  • Purity ≥98%
  • MDL No. MFCD08146650
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO₃
  • Molecular Weight 184.16
  • Synonym(s) None
  • SMILES O=C(O)CC1=CC=C(F)C(OC)=C1

Description

4-Fluoro-3-methoxybenzeneacetic acid features a strategically positioned fluorine atom and methoxy group that modulate electronic properties and lipophilicity. This combination enhances metabolic stability while maintaining favorable solubility characteristics for use in medicinal chemistry scaffolds and bioactive compound synthesis under standard conditions.

Application

4-Fluoro-3-methoxybenzeneacetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard coupling and functionalization reactions. Its ortho-fluoro and meta-methoxy substituents provide enhanced metabolic stability and modulated electronic properties, while the carboxylic acid group facilitates direct amide, ester, or acyl chloride formation. The compound exhibits good bench stability and is readily purified by recrystallization or chromatography, supporting its use in scalable API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.4614
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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