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CS-W001157 4
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(1S,3S)-3-Aminocyclopentan-1-ol

  • CAS No. 946593-67-5

  • Cat. No. CS-0131617
  • Molecule weight101.15
  • Purity≥95%
  • MDL No.MFCD11052499

*For research and further manufacturing use only, not for direct human use.

(1S,3S)-3-Aminocyclopentan-1-ol|CS-0131617

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General Information

  • CAS No. 946593-67-5
  • Cat. No. CS-0131617
  • Purity ≥95%
  • MDL No. MFCD11052499
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO
  • Molecular Weight 101.15
  • Synonym(s) (1S,3S)-3-Aminocyclopentanol
  • SMILES O[C@@H]1C[C@@H](N)CC1

Description

This chiral cyclopentanediol derivative features a stereochemically defined amino group and hydroxyl moiety, enabling precise integration into bioactive scaffolds. The (1S,3S) configuration ensures high enantioselectivity in asymmetric synthesis, while the molecule's rigidity and hydrogen-bonding capacity support stable conformational control in medicinal chemistry applications.

Application

(1S,3S)-3-Aminocyclopentan-1-ol serves as a key chiral building block in medicinal chemistry, offering a rigid, conformationally defined scaffold with orthogonal functional groups. The amine and hydroxyl moieties enable diverse derivatization via standard coupling, protection, and cyclization strategies. Its bench-stable solid form and compatibility with common reaction conditions facilitate integration into multi-step syntheses of bioactive molecules and heterocyclic frameworks.

Synthesis

  • Route1

    References

    • Thompson, Wayne; Young, Steven D.; Phillips, Brian T.; Munson, Peter; Whitter, Willie; Liverton, Nigel; Dieckhaus, Christine; Butcher, John; McCauley, John A.; McIntyre, Charles J.; Layton, Mark E.; Sanderson, Philip E. Patent: US2005/54658 A1, 2005 ; Location in patent: Page/Page column 49 ; US 20050054658 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Warning
UN#: 1325
Class : 4.1
Packing Group : Ⅱ
Hazard Statements : H228
Precautionary Statements : P210-P240-P241-P280-P370+P378

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   -0.1415
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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