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CS-W001157 4
Total: USD 88.00

B-[4-(Difluoromethyl)phenyl]boronic acid

  • CAS No. 946525-43-5

  • Cat. No. CS-0030626
  • Purity≥98%
  • MDL No.MFCD09056705

*For research and further manufacturing use only, not for direct human use.

B-[4-(Difluoromethyl)phenyl]boronic acid|CS-0030626

Structure of 946525-43-5

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General Information

  • CAS No. 946525-43-5
  • Cat. No. CS-0030626
  • Purity ≥98%
  • MDL No. MFCD09056705
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BF₂O₂
  • Molecular Weight 171.94
  • Synonym(s) B-[4-(Difluoromethyl)phenyl]boronic acid
  • SMILES FC(C1=CC=C(B(O)O)C=C1)F

Description

This boronate moiety integrates a difluoromethyl group at the para position of a phenyl ring, delivering enhanced metabolic stability and electron-deficient character. The functional group enables efficient Suzuki-Miyaura coupling under standard conditions, facilitating rapid access to fluorinated biaryl scaffolds in medicinal chemistry and materials science applications.

Application

(4-(Difluoromethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds with enhanced metabolic stability. The difluoromethyl group imparts favorable electronic and lipophilic properties, improving bioavailability in medicinal chemistry applications. Its bench-stable nature and compatibility with diverse functional groups facilitate straightforward purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.304
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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