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CS-W001157 4
Total: USD 88.00

2-(Trifluoromethoxy)benzaldehyde

  • CAS No. 94651-33-9

  • Cat. No. CS-W015915
  • Purity≥95%
  • MDL No.MFCD00042405

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethoxy)benzaldehyde|CS-W015915

Structure of 94651-33-9

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General Information

  • CAS No. 94651-33-9
  • Cat. No. CS-W015915
  • Purity ≥95%
  • MDL No. MFCD00042405
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃O₂
  • Molecular Weight 190.12
  • Synonym(s) 2-Trifluoromethoxybenzaldehyde; 2-(Trifluoromethoxy)benzaldehyde
  • SMILES O=CC1=CC=CC=C1OC(F)(F)F

Description

2-(Trifluoromethoxy)benzaldehyde may be used in the synthesis of tert-butyl N-[4-chloro-2-[-hydroxy--2-(trifluoromethoxy)phenyl]]carbamate.

Application

2-(Trifluoromethoxy)benzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling the synthesis of biologically active heterocycles and functionalized aromatics. Its electron-withdrawing trifluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the aldehyde functionality facilitates standard transformations including reductive amination, Wittig reactions, and condensation with hydrazines or amines. The compound exhibits good bench stability and is readily purified by distillation or recrystallization, making it well-suited for scalable synthetic workflows.

Synthesis

  • Route1
    • null|null
      456-55-3
    • null|null
      68-12-2
    • ~95%
    • In-stock
      2-(Trifluoromethoxy)benzaldehyde|CS-W015915
      94651-33-9

    References

    • Castagnetti, Eva; Schlosser, Manfred European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
  • Route2
    • null|null
      1262424-69-0
    • ~%
    • In-stock
      2-(Trifluoromethoxy)benzaldehyde|CS-W015915
      94651-33-9

    References

    • Beilstein Journal of Organic Chemistry, , vol. 6, p. 1061 - 1069

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.3977
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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