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CS-W001157 4
Total: USD 88.00

nNOS-IN-1

  • CAS No. 945762-00-5

  • Cat. No. CS-0040362
  • Purity≥98%
  • MDL No.MFCD11848409

*For research and further manufacturing use only, not for direct human use.

nNOS-IN-1|CS-0040362

Structure of 945762-00-5

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General Information

  • CAS No. 945762-00-5
  • Cat. No. CS-0040362
  • Purity ≥98%
  • MDL No. MFCD11848409
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄BrN₃
  • Molecular Weight 222.04
  • Synonym(s) None
  • SMILES N#CC1=CC=CC2=C1NN=C2Br

Description

nNOS-IN-1 is a potent, selective inhibitor of neuronal nitric oxide synthase, designed for precise modulation of NO signaling pathways. This compound exhibits high affinity for nNOS over other NOS isoforms, enabling targeted investigation of neuroinflammatory and neurodegenerative processes in preclinical models.

Application

nNOS-IN-1 serves as a well-characterized, selective inhibitor of neuronal nitric oxide synthase (nNOS), enabling targeted investigation of nitric oxide-mediated signaling pathways in neurological and inflammatory contexts. Its stability and cell-permeable properties facilitate consistent performance in cellular assays and in vivo models, supporting mechanistic studies in neurodegenerative disease research and vascular physiology.

Synthesis

  • Route1

    References

    • Cottyn, Betty; Acher, Francine; Ramassamy, Booma; Alvey, Luke; Lepoivre, Michel; Frapart, Yves; Stuehr, Dennis; Mansuy, Daniel; Boucher, Jean-Luc; Vichard, Dominique Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5962 - 5973
  • Route2
    • 3-Bromo-7-iodo-2h-indazole|CS-0679489
      945761-95-5
    • null|null
      557-21-1
    • ~52%
    • In-stock
      nNOS-IN-1|CS-0040362
      945762-00-5

    References

    • Cottyn, Betty; Vichard, Dominique; Terrier, Francois; Nioche, Pierre; Raman Synlett, 2007 , # 8 p. 1203 - 1206
  • Route3

    References

    • Synlett, , # 8 p. 1203 - 1206

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.47
  • LogP   2.19708
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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