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CS-W001157 4
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3-Bromo-6-chloroimidazo[1,2-a]pyrimidine

  • CAS No. 944906-48-3

  • Cat. No. CS-0041795
  • Purity≥98%
  • MDL No.MFCD10697389

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-chloroimidazo[1,2-a]pyrimidine|CS-0041795

Structure of 944906-48-3

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General Information

  • CAS No. 944906-48-3
  • Cat. No. CS-0041795
  • Purity ≥98%
  • MDL No. MFCD10697389
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClN₃
  • Molecular Weight 232.47
  • Synonym(s) None
  • SMILES ClC1=CN2C(N=C1)=NC=C2Br

Description

3-Bromo-6-chloroimidazo[1,2-a]pyrimidine features a fused heterocyclic core with orthogonal halogen substituents enabling selective cross-coupling. This electron-deficient scaffold integrates readily into bioactive molecule design, offering enhanced reactivity in palladium-catalyzed transformations under standard conditions.

Application

3-Bromo-6-chloroimidazo[1,2-a]pyrimidine serves as a versatile building block for the synthesis of imidazopyrimidine-based scaffolds prevalent in medicinal chemistry. Its complementary halogenation pattern enables sequential cross-coupling reactions, facilitating the construction of complex heterocycles with high regiocontrol. The compound exhibits excellent bench stability and compatibility with palladium-catalyzed coupling protocols, making it well-suited for iterative synthetic strategies in drug discovery and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   2.1452
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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