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CS-W001157 4
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5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine

  • CAS No. 944401-57-4

  • Cat. No. CS-M0295
  • Purity≥98%
  • MDL No.MFCD12923420

*For research and further manufacturing use only, not for direct human use.

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine|CS-M0295

Structure of 944401-57-4

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General Information

  • CAS No. 944401-57-4
  • Cat. No. CS-M0295
  • Purity ≥98%
  • MDL No. MFCD12923420
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆BF₃N₂O₂
  • Molecular Weight 288.07
  • Synonym(s) 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine
  • SMILES FC(F)(F)C1=C(C=NC(N)=C1)B(OC(C)2C)OC2(C)C

Description

(S)-T-GNA phosphoramidite is a monophosphate nucleoside that can be modified to form DNA, RNA, or ribonucleosides. The fluorine atom on the benzoyl moiety confers resistance to degradation by nucleases.

Synthesis

  • Route1

    References

    • Burger, Matthew T.; Pecchi, Sabina; Wagman, Allan; Ni, Zhi-Jie; Knapp, Mark; Hendrickson, Thomas; Atallah, Gordana; Pfister, Keith; Zhang, Yanchen; Bartulis, Sarah; Frazier, Kelly; Ng, Simon; Smith, Aaron; Verhagen, Joelle; Haznedar, Joshua; Huh, Kay; Iwanowicz, Ed; Xin, Xiaohua; Menezes, Daniel; Merritt, Hanne; Lee, Isabelle; Wiesmann, Marion; Kaufman, Susan; Crawford, Kenneth; Chin, Michael; Bussiere, Dirksen; Shoemaker, Kevin; Zaror, Isabel; Maira, Sauveur-Michel; Voliva, Charles F. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 774 - 779
  • Route2

    References

    • WO2010/52569 A2, ; Page/Page column 221-222 ; WO 2010/052569 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.37
  • LogP   1.9818
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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