5-Bromo-4-(trifluoromethyl)pyridin-2-amine

Name: 5-Bromo-4-(trifluoromethyl)pyridin-2-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 944401-56-3
Cat. No. CS-M0294
Purity≥95%
MDL No.MFCD09864896

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-4-(trifluoromethyl)pyridin-2-amine|CS-M0294

Structure of 944401-56-3

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 944401-56-3
Cat. No. CS-M0294
Purity ≥95%
MDL No. MFCD09864896
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄BrF₃N₂
Molecular Weight 241.01
Synonym(s) 2-amino-5-bromo-4-(trifluoromethyl)pyridine
SMILES FC(F)(F)C1=C(Br)C=NC(N)=C1

Description

5-Bromo-4-(trifluoromethyl)pyridin-2-amine features a bromine atom at the 5-position and a trifluoromethyl group at the 4-position of the pyridine ring, creating a highly electron-deficient heterocyclic scaffold. This configuration enables efficient cross-coupling reactions in medicinal chemistry and materials synthesis. The amine functionality provides a reactive handle for further derivatization under mild conditions.

Application

5-Bromo-4-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. The bromo group enables palladium-catalyzed coupling with boronic acids, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity. Its pyridine amine functionality provides a handle for further derivatization, including amidation or electrophilic substitution. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthesis of complex heterocyclic scaffolds.

Synthesis

Route1
- In-stock
  
  106447-97-6
- ~82%
- In-stock
  
  944401-56-3
References
- Burger, Matthew T.; Pecchi, Sabina; Wagman, Allan; Ni, Zhi-Jie; Knapp, Mark; Hendrickson, Thomas; Atallah, Gordana; Pfister, Keith; Zhang, Yanchen; Bartulis, Sarah; Frazier, Kelly; Ng, Simon; Smith, Aaron; Verhagen, Joelle; Haznedar, Joshua; Huh, Kay; Iwanowicz, Ed; Xin, Xiaohua; Menezes, Daniel; Merritt, Hanne; Lee, Isabelle; Wiesmann, Marion; Kaufman, Susan; Crawford, Kenneth; Chin, Michael; Bussiere, Dirksen; Shoemaker, Kevin; Zaror, Isabel; Maira, Sauveur-Michel; Voliva, Charles F. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 774 - 779

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 38.91
LogP 2.4451
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

944401-56-3 sigma944401-56-3 manufacturer944401-56-3 price944401-56-3 structure944401-56-3 SDSbuy 944401-56-3944401-56-3 supplier944401-56-3 uses944401-56-3 molecular weightprice of 944401-56-3944401-56-3 chemical name formula of 944401-56-3

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

5-Bromo-4-(trifluoromethyl)pyridin-2-amine

CAS No. 944401-56-3

Recommended Products