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CS-W001157 4
Total: USD 88.00

3-Bromo-6-chloro-2-fluoroaniline

  • CAS No. 943830-81-7

  • Cat. No. CS-0098646
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-chloro-2-fluoroaniline|CS-0098646

Structure of 943830-81-7

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General Information

  • CAS No. 943830-81-7
  • Cat. No. CS-0098646
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrClFN
  • Molecular Weight 224.46
  • Synonym(s) 3-Bromo-6-chloro-2-fluoro-phenylamine
  • SMILES NC1=C(Cl)C=CC(Br)=C1F

Description

3-Bromo-6-chloro-2-fluoroaniline features a trihalogenated aromatic core with strategic electronic tuning from the fluorine, chlorine, and bromine substituents. This electron-deficient scaffold enables direct coupling in cross-coupling reactions and serves as a high-performance building block for pharmaceutical intermediates and functional materials.

Application

3-Bromo-6-chloro-2-fluoroaniline serves as a versatile building block in the synthesis of functionalized aromatic scaffolds, particularly for pharmaceutical and agrochemical intermediates. Its orthogonal halogenation pattern enables selective cross-coupling reactions under palladium catalysis, facilitating efficient C–C and C–heteroatom bond formation. The molecule exhibits good bench stability and is compatible with common protecting group strategies, simplifying purification and downstream derivatization in multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.8238
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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