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Structure of 941294-25-3
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1,3-Dichloro-7-fluoroisoquinoline features a sterically accessible isoquinoline core with strategically positioned halogens enabling direct functionalization. The electron-deficient ring system facilitates cross-coupling reactions under mild conditions, while the fluorine substituent enhances metabolic stability and modulates electronic properties. This compound serves as a key building block for bioactive heterocycles in medicinal chemistry.
1,3-Dichloro-7-fluoroisoquinoline serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization at the C-2 and C-4 positions via palladium-catalyzed cross-coupling. Its fluorinated isoquinoline core provides enhanced metabolic stability and improved membrane permeability, while the dichloro substituents offer orthogonal reactivity for sequential derivatization. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for scalable synthesis of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: