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CS-W001157 4
Total: USD 88.00

2,4,6-Trimethylbenzoyl Chloride

  • CAS No. 938-18-1

  • Cat. No. CS-W017077
  • Molecule weight182.65
  • Purity≥97%
  • MDL No.MFCD00013650

*For research and further manufacturing use only, not for direct human use.

2,4,6-Trimethylbenzoyl Chloride|CS-W017077

Structure of 938-18-1

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General Information

  • CAS No. 938-18-1
  • Cat. No. CS-W017077
  • Purity ≥97%
  • MDL No. MFCD00013650
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁ClO
  • Molecular Weight 182.65
  • Synonym(s) None
  • SMILES O=C(Cl)C1=C(C)C=C(C)C=C1C

Description

This acyl chloride features three methyl groups positioned at the 2, 4, and 6 ring sites, creating a sterically hindered yet highly reactive electrophilic center. It enables efficient incorporation of the trimethylbenzoyl moiety into synthetic architectures under mild conditions, offering enhanced stability compared to unsubstituted analogs while maintaining high reactivity in amide and ester formation.

Application

2,4,6-Trimethylbenzoyl chloride serves as a robust acylating agent for the introduction of a sterically hindered benzoyl group under mild conditions. Its tertiary α-carbon enhances stability and reduces undesired side reactions, enabling selective amide formation with amines and alcohols. The bulky trimethylphenyl moiety facilitates purification by crystallization and imparts excellent functional group tolerance in complex molecule synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   N/A
  • LogP   N/A
  • H_Acceptors   N/A
  • H_Donors   N/A
  • Rotatable_Bonds   N/A

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