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Structure of 938-18-1
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This acyl chloride features three methyl groups positioned at the 2, 4, and 6 ring sites, creating a sterically hindered yet highly reactive electrophilic center. It enables efficient incorporation of the trimethylbenzoyl moiety into synthetic architectures under mild conditions, offering enhanced stability compared to unsubstituted analogs while maintaining high reactivity in amide and ester formation.
2,4,6-Trimethylbenzoyl chloride serves as a robust acylating agent for the introduction of a sterically hindered benzoyl group under mild conditions. Its tertiary α-carbon enhances stability and reduces undesired side reactions, enabling selective amide formation with amines and alcohols. The bulky trimethylphenyl moiety facilitates purification by crystallization and imparts excellent functional group tolerance in complex molecule synthesis.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: