Lot numbers can be found on the outside label of a product:
DMT-dI
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CAS No. 93778-57-5
- Cat. No. CS-W011460
- Purity≥98%
- MDL No.MFCD00057879
*For research and further manufacturing use only, not for direct human use.
Structure of 93778-57-5
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General Information
- CAS No. 93778-57-5
- Cat. No. CS-W011460
- Purity ≥98%
- MDL No. MFCD00057879
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₃₁H₃₀N₄O₆
- Molecular Weight 554.59
- Synonym(s) 5'-O-DMT-dI; 2'-Deoxy-5'-O-DMT-inosine
- SMILES O[C@H]1C[C@H](N2C(N=CNC3=O)=C3N=C2)O[C@@H]1COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6
Description
DMT-dI delivers a robust, bench-stable phosphoramidite for rapid oligonucleotide synthesis. This derivative features a protected 5′-hydroxyl group and a dimethoxytrityl (DMT) chromophore, enabling efficient coupling and real-time monitoring during solid-phase assembly. The dI moiety ensures high incorporation fidelity and compatibility with standard deprotection protocols.
Application
DMT-dI serves as a reliable building block for the synthesis of nucleoside analogs, enabling efficient coupling reactions under standard phosphoramidite conditions. Its dimethoxytrityl (DMT) group provides excellent protection and facilitates purification via chromatography, while the deoxyinosine (dI) moiety offers a stable, functionally versatile scaffold for oligonucleotide assembly and medicinal chemistry applications.
Synthesis
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Route1
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890-38-0 -
In-stock
40615-36-9 - ~79%
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In-stock
93778-57-5
References
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Zeidler, Joanna; Golankiewicz, Bozenna Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 1077 - 1095
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Route2
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1254223-76-1 - ~%
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In-stock
93778-57-5
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 4 p. 1181 - 1184
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Route3
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In-stock
40615-36-9
- ~%
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In-stock
93778-57-5
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 4 p. 1181 - 1184
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P280-P302+P352
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Quality Control
Computational Chemistry Data
- TPSA 120.72
- LogP 3.7939
- H_Acceptors 9
- H_Donors 2
- Rotatable_Bonds 9
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