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CS-W001157 4
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(S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride

  • CAS No. 935667-21-3

  • Cat. No. CS-M0358
  • Molecule weight177.61
  • Purity≥98%
  • MDL No.MFCD18207119

*For research and further manufacturing use only, not for direct human use.

(S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride|CS-M0358

Structure of 935667-21-3

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General Information

  • CAS No. 935667-21-3
  • Cat. No. CS-M0358
  • Purity ≥98%
  • MDL No. MFCD18207119
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉ClFN₃
  • Molecular Weight 177.61
  • Synonym(s) (S)-1-(5-fluoropyrimidin-2-yl)ethan-1-amine hydrochloride
  • SMILES C[C@H](N)C1=NC=C(F)C=N1.[H]Cl

Synthesis

  • Route1
    • Tert-butyl (S)-(1-(5-fluoropyrimidin-2-yl)ethyl)carbamate|CS-0562833
      905587-30-6
    • ~99%
    • In-stock
      (S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride|CS-M0358
      935667-21-3

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2008/129255 A1, 2008 ; Location in patent: Page/Page column 72 ; WO 2008/129255 A1
  • Route2
    • N-((S)-1-(5-Fluoropyrimidin-2-yl)ethyl)-2-methylpropane-2-sulfinamide|CS-0997170
      935667-52-0
    • ~99%
    • In-stock
      (S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride|CS-M0358
      935667-21-3

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2007/49041 A1, 2007 ; Location in patent: Page/Page column 73 ; WO 2007/049041 A1
  • Route3

    References

    • Frodsham, Lianne; Golden, Michael; Hard, Susan; Kenworthy, Martin N.; Klauber, David J.; Leslie, Kevin; Macleod, Claire; Meadows, Rebecca E.; Mulholland, Keith R.; Reilly, Julie; Squire, Christopher; Tomasi, Simone; Watt, Denise; Wells, Andrew S. Organic Process Research and Development, 2013 , vol. 17, # 9 p. 1123 - 1130

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.0572
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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