Lot numbers can be found on the outside label of a product:
Tert-butyldiphenylsilanol
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CAS No. 93547-88-7
- Cat. No. CS-0458752
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 93547-88-7
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General Information
- CAS No. 93547-88-7
- Cat. No. CS-0458752
- Purity ≥98%
- MDL No. None
- Storage Store at room temperature, keep dry and cool
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₆H₂₀OSi
- Molecular Weight 256.41
- Synonym(s) Silanol, (1,1-dimethylethyl)diphenyl-
- SMILES O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C(C)(C)C
Description
Tert-butyldiphenylsilanol offers a sterically shielded silanol group ideal for selective silylation reactions. The bulky tert-butyl and diphenyl substituents confer exceptional bench stability and moisture tolerance, enabling reliable handling under standard conditions. This reagent integrates seamlessly into synthetic workflows requiring protected silicon functionalities without unwanted side reactions.
Application
Tert-butyldiphenylsilanol serves as a stable, bench-friendly silyl protecting group reagent, enabling reliable protection of alcohols and carboxylic acids under mild conditions. Its steric bulk facilitates selective deprotection and enhances functional group tolerance in complex molecule synthesis. Widely used in medicinal chemistry and natural product synthesis, it functions effectively in nucleophilic substitution and coupling reactions, offering high stability during purification and storage.
Synthesis
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Route1
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139706-45-9 - ~80%
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In-stock
93547-88-7
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108-88-3
References
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Igarashi, Masayasu; Matsumoto, Tomohiro; Sato, Kazuhiko; Ando, Wataru; Shimada, Shigeru Chemistry Letters, 2014 , vol. 43, # 4 p. 429 - 431
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Route2
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58479-61-1
- ~99%
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In-stock
93547-88-7
References
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Mullen, Daniel G.; Barany, George Journal of Organic Chemistry, 1988 , vol. 53, # 22 p. 5240 - 5248
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Route3
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1110667-77-0
- ~18%
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In-stock
93547-88-7
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172995-33-4
References
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Moynihan, Meghan F.; Tucker, Joseph W.; Abelt, Christopher J. Synthesis, 2008 , # 22 p. 3565 - 3568
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Quality Control
Computational Chemistry Data
- TPSA 20.23
- LogP 2.5387
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 2
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