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CS-W001157 4
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5,6-Dihydro-4H-cyclopenta[d]thiazole-2-carbaldehyde

  • CAS No. 933728-60-0

  • Cat. No. CS-0488540
  • Purity≥98%
  • MDL No.MFCD10700212

*For research and further manufacturing use only, not for direct human use.

5,6-Dihydro-4H-cyclopenta[d]thiazole-2-carbaldehyde|CS-0488540

Structure of 933728-60-0

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General Information

  • CAS No. 933728-60-0
  • Cat. No. CS-0488540
  • Purity ≥98%
  • MDL No. MFCD10700212
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NOS
  • Molecular Weight 153.20
  • Synonym(s) 4H,5H,6H-cyclopenta[d][1,3]thiazole-2-carbaldehyde
  • SMILES O=CC1=NC2=C(CCC2)S1

Description

This electron-deficient heterocycle features a reactive aldehyde group flanked by a saturated cyclopentane ring and a thiazole scaffold. The fused structure imparts stability while enabling selective functionalization at the carbonyl site, making it valuable for constructing complex molecular architectures in medicinal chemistry and materials synthesis.

Application

5,6-Dihydro-4H-cyclopenta[d]thiazole-2-carbaldehyde serves as a versatile heterocyclic building block for medicinal chemistry and synthetic organic applications. The aldehyde functionality enables direct derivatization via reductive amination, Wittig reactions, or Grignard additions, while the fused thiazole ring provides structural rigidity and favorable electronic properties. Bench-stable and compatible with standard purification methods, it facilitates efficient access to complex scaffolds in drug discovery campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.4443
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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