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CS-W001157 4
Total: USD 88.00

4-Aminopyrimidine-2-carboxylic acid

  • CAS No. 933703-11-8

  • Cat. No. CS-0372636
  • Purity≥97%
  • MDL No.MFCD11977609

*For research and further manufacturing use only, not for direct human use.

4-Aminopyrimidine-2-carboxylic acid|CS-0372636

Structure of 933703-11-8

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General Information

  • CAS No. 933703-11-8
  • Cat. No. CS-0372636
  • Purity ≥97%
  • MDL No. MFCD11977609
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅N₃O₂
  • Molecular Weight 139.11
  • Synonym(s) None
  • SMILES O=C(C1=NC=CC(N)=N1)O

Description

4-Aminopyrimidine-2-carboxylic acid features a dual functional group architecture: an electron-rich amino group and a carboxylic acid moiety positioned at opposing ring vertices. This arrangement enables versatile conjugation in medicinal chemistry, particularly in kinase inhibitor scaffolds and bioactive heterocycles. The compound exhibits enhanced solubility and stability under standard conditions, facilitating integration into multi-step synthesis workflows.

Application

4-Aminopyrimidine-2-carboxylic acid serves as a versatile scaffold for constructing bioactive heterocycles, enabling efficient derivatization via amide coupling, alkylation, and metal-catalyzed cross-coupling reactions. Its dual functionality—amine and carboxylic acid—facilitates orthogonal transformations, supporting modular synthesis of pharmaceutical intermediates. The compound exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   89.1
  • LogP   -0.243
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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