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CS-W001157 4
Total: USD 88.00

1-(2-Fluoro-6-hydroxyphenyl)ethanone

  • CAS No. 93339-98-1

  • Cat. No. CS-W005023
  • Purity≥98%
  • MDL No.MFCD01090995

*For research and further manufacturing use only, not for direct human use.

1-(2-Fluoro-6-hydroxyphenyl)ethanone|CS-W005023

Structure of 93339-98-1

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General Information

  • CAS No. 93339-98-1
  • Cat. No. CS-W005023
  • Purity ≥98%
  • MDL No. MFCD01090995
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) Ethanone, 1-(2-fluoro-6-hydroxyphenyl)-
  • SMILES CC(C1=C(O)C=CC=C1F)=O

Description

1-(2-Fluoro-6-hydroxyphenyl)ethanone features a fluorinated aromatic ring bearing a hydroxyl group at the para position relative to the ketone, enhancing its polarity and hydrogen-bonding capacity. This scaffold integrates readily into bioactive molecule design, offering improved solubility and metabolic stability in pharmaceutical intermediates.

Application

1-(2-Fluoro-6-hydroxyphenyl)ethanone serves as a versatile building block for fluorinated aromatic ketones, enabling efficient access to bioactive scaffolds. Its hydroxyl and fluoro substituents offer orthogonal reactivity for downstream functionalization, including etherification, esterification, and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and process development in API synthesis.

Synthesis

  • Route1

    References

    • Rhizen Pharmaceuticals SA Patent: US2012/289496 A1, 2012 ; Location in patent: Page/Page column 100 ;
  • Route2

    References

    • WO2012/151525 A1, ; WO 2012/151525 A1
  • Route3

    References

    • WO2012/151525 A1, ; WO 2012/151525 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.7339
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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