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CS-W001157 4
Total: USD 88.00

6-Chloro-2-methylpyrimidine-4,5-diamine

  • CAS No. 933-80-2

  • Cat. No. CS-0045785
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-methylpyrimidine-4,5-diamine|CS-0045785

Structure of 933-80-2

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General Information

  • CAS No. 933-80-2
  • Cat. No. CS-0045785
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇ClN₄
  • Molecular Weight 158.59
  • Synonym(s) 6-chloro-4,5-diamino-2-methylpyrimidine
  • SMILES NC1=NC(C)=NC(Cl)=C1N

Description

6-Chloro-2-methylpyrimidine-4,5-diamine features a pyrimidine core bearing chlorine and methyl substituents at the 6- and 2-positions, respectively, with diamine functionality at C4 and C5. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, serving as a key building block for kinase inhibitors and antiviral agents. The molecule exhibits favorable reactivity under standard coupling conditions and demonstrates stability in common organic solvents.

Application

6-Chloro-2-methylpyrimidine-4,5-diamine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds common in medicinal chemistry. The chloro group facilitates palladium-catalyzed cross-coupling reactions, while the diamine functionality supports derivatization via alkylation, acylation, or cyclization. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis workflows and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   77.82
  • LogP   0.60282
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   0

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