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CS-W001157 4
Total: USD 88.00

Tetramethylcyclobutane-1,3-dione

  • CAS No. 933-52-8

  • Cat. No. CS-0047858
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Tetramethylcyclobutane-1,3-dione|CS-0047858

Structure of 933-52-8

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General Information

  • CAS No. 933-52-8
  • Cat. No. CS-0047858
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂O₂
  • Molecular Weight 140.18
  • Synonym(s) Tetramethylcyclobuta-1,3-dione
  • SMILES CC1(C)C(=O)C(C)(C)C1=O

Description

Tetramethylcyclobutane-1,3-dione features two carbonyl groups flanked by methyl substituents on a strained cyclobutane ring, enhancing its reactivity in cycloaddition and condensation reactions. This electron-deficient scaffold serves as a robust building block for synthesizing complex heterocycles and natural product analogs under standard conditions.

Application

Tetramethylcyclobutane-1,3-dione serves as a versatile synthon in organic synthesis, enabling efficient construction of substituted cyclohexane and pyran scaffolds via Diels-Alder reactions. Its enhanced stability and defined regiochemistry facilitate reliable heterocycle formation under mild conditions. The molecule’s four methyl groups provide steric protection and improve solubility, simplifying purification and enhancing compatibility with diverse functional groups in multi-step sequences.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   1.1906
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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