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Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4,6-Dichloro-1,3,5-triazin-2-amine

  • CAS No. 933-20-0

  • Cat. No. CS-W008081
  • Purity≥95%
  • MDL No.MFCD00078331

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloro-1,3,5-triazin-2-amine|CS-W008081

Structure of 933-20-0

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General Information

  • CAS No. 933-20-0
  • Cat. No. CS-W008081
  • Purity ≥95%
  • MDL No. MFCD00078331
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₂Cl₂N₄
  • Molecular Weight None
  • Synonym(s) s-Triazine, 2-amino-4,6-dichloro-
  • SMILES NC1=NC(Cl)=NC(Cl)=N1

Description

4,6-Dichloro-1,3,5-triazin-2-amine features a highly reactive triazine core with two chlorine substituents at the 4 and 6 positions, enabling efficient coupling to nucleophiles such as amines and hydroxyl groups. This bench-stable reagent facilitates rapid formation of amide and ester linkages under mild conditions, making it ideal for conjugation workflows in peptide synthesis, antibody-drug conjugate development, and polymer functionalization.

Synthesis

  • Route1
    • null|null
      108-77-0
    • ~88%
    • In-stock
      4,6-Dichloro-1,3,5-triazin-2-amine|CS-W008081
      933-20-0

    References

    • Zerkowski, Jonathan A.; MacDonald, John C.; Seto, Christopher T.; Wierda, Derk A.; Whitesides, George M. Journal of the American Chemical Society, 1994 , vol. 116, # 6 p. 2382 - 2391
  • Route2
    • null|null
      1336-21-6
    • null|null
      108-77-0
    • ~87%
    • In-stock
      4,6-Dichloro-1,3,5-triazin-2-amine|CS-W008081
      933-20-0

    References

    • Pfizer Inc. Patent: US5536722 A1, 1996 ;
  • Route3
    • null|null
      108-77-0
    • ~%
    • In-stock
      4,6-Dichloro-1,3,5-triazin-2-amine|CS-W008081
      933-20-0
    • In-stock
      6-Chloro-1,3,5-triazine-2,4-diamine|CS-W018245
      3397-62-4

    References

    • Journal of Organic Chemistry, , vol. 23, p. 1802 C: MVol.D3, 7.2.8.5, page 284 - 285

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.69
  • LogP   0.7606
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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