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CS-W001157 4
Total: USD 88.00

4,4-Dimethylcyclohexanol

  • CAS No. 932-01-4

  • Cat. No. CS-W019410
  • Purity≥97%
  • MDL No.MFCD00101954

*For research and further manufacturing use only, not for direct human use.

4,4-Dimethylcyclohexanol|CS-W019410

Structure of 932-01-4

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General Information

  • CAS No. 932-01-4
  • Cat. No. CS-W019410
  • Purity ≥97%
  • MDL No. MFCD00101954
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆O
  • Molecular Weight 128.21
  • Synonym(s) 4,4-Dimethylcyclohexan-1-OL
  • SMILES CC1(CCC(O)CC1)C

Description

4,4-Dimethylcyclohexanol features a sterically hindered tertiary alcohol group within a cyclohexane ring, enhancing its stability and resistance to oxidation. This bench-stable compound integrates readily into synthetic routes requiring robust, moisture-tolerant hydroxyl functionality.

Application

4,4-Dimethylcyclohexanol serves as a stable, bench-ready building block for cycloaliphatic scaffolds in medicinal and materials chemistry. Its tertiary alcohol functionality enables straightforward derivatization via dehydration, oxidation, or esterification, while the geminal dimethyl groups enhance steric shielding and metabolic stability. The compound exhibits excellent solubility in common organic solvents and facilitates clean purification, making it well-suited for multi-step synthesis and scale-up applications.

Synthesis

  • Route1

    References

    • Aramini, Andrea; Brinchi, Lucia; Germani, Raimondo; Savelli, Gianfranco European Journal of Organic Chemistry, 2000 , # 9 p. 1793 - 1797
  • Route2

    References

    • Liu, Kevin K.-C.; Lefker, Bruce A.; Dombroski, Mark A.; Chiang, Phoebe; Cornelius, Peter; Patterson, Terrell A.; Zeng, Yuan; Santucci, Stephanie; Tomlinson, Elizabeth; Gibbons, Colleen P.; Marala, Ravi; Brown, Janice A.; Kong, Jimmy X.; Lee, Eunsun; Werner, Wendy; Wenzel, Zane; Giragossian, Craig; Chen, Hou; Coffey, Steven B. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 7 p. 2365 - 2369
  • Route3
    • null|null
      634905-74-1
    • ~52%
    • In-stock
      4,4-Dimethylcyclohexanol|CS-W019410
      932-01-4

    References

    • Clive, Derrick L. J.; Cheng, Hua Synthetic Communications, 2003 , vol. 33, # 11 p. 1951 - 1961

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.9475
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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