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Structure of 93107-30-3
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1-Cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid features a rigid quinoline core with strategically positioned fluorine atoms enhancing membrane permeability and metabolic stability. The cyclopropyl group at C-1 imparts conformational constraint, while the carboxylic acid at C-3 enables direct conjugation or derivatization in medicinal chemistry campaigns targeting Gram-negative pathogens.
1-Cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid serves as a key scaffold in medicinal chemistry, enabling the synthesis of fluoroquinolone-based bioactive molecules. Its difluorinated core enhances metabolic stability and membrane permeability, while the carboxylic acid group facilitates conjugation via amide or ester linkages. The cyclopropyl substitution improves target binding affinity and overall pharmacokinetic profile. This compound exhibits bench stability and compatibility with standard peptide coupling and heterocyclic functionalization protocols, making it a practical building block for API development and analog library synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: