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CS-W001157 4
Total: USD 88.00

Naphthalene-2-sulfonyl chloride

  • CAS No. 93-11-8

  • Cat. No. CS-W004905
  • Purity≥97%
  • MDL No.MFCD00004087

*For research and further manufacturing use only, not for direct human use.

Naphthalene-2-sulfonyl chloride|CS-W004905

Structure of 93-11-8

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General Information

  • CAS No. 93-11-8
  • Cat. No. CS-W004905
  • Purity ≥97%
  • MDL No. MFCD00004087
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇ClO₂S
  • Molecular Weight None
  • Synonym(s) 2-Naphthalenesulfonyl chloride
  • SMILES O=S(C1=CC=C2C=CC=CC2=C1)(Cl)=O

Description

2-Naphthalenesulfonyl chloride was employed as capping reagent for primary amine to convert histamine to a selective histamine H3-receptor antagonist. It was used for pre-column derivatization during the high-performance liquid chromatographic assay of neomycin sulfate.

Application

Naphthalene-2-sulfonyl chloride serves as a robust sulfonating agent for amine functionalization, enabling efficient synthesis of sulfonamide derivatives under mild conditions. Its stability and ease of handling facilitate straightforward purification, while the naphthalene scaffold provides enhanced solubility and orthogonal reactivity in complex molecule assembly. Widely used in medicinal chemistry and agrochemical synthesis, it functions reliably in standard coupling protocols and supports scalable, high-yield transformations.

Synthesis

  • Route1
    • null|null
      91-60-1
    • ~98%
    • In-stock
      Naphthalene-2-sulfonyl chloride|CS-W004905
      93-11-8

    References

    • Veisi, Hojat; Sedrpoushan, Alireza; Hemmati, Saba; Kordestani, Davood Phosphorus, Sulfur and Silicon and the Related Elements, 2012 , vol. 187, # 6 p. 769 - 775
  • Route2
    • null|null
      5586-15-2
    • ~98%
    • In-stock
      Naphthalene-2-sulfonyl chloride|CS-W004905
      93-11-8

    References

    • Veisi, Hojat; Sedrpoushan, Alireza; Hemmati, Saba; Kordestani, Davood Phosphorus, Sulfur and Silicon and the Related Elements, 2012 , vol. 187, # 6 p. 769 - 775
  • Route3

    References

    • Fujita, Shinsaku Synthesis, 1982 , # 5 p. 423 - 424

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H315-H411
Precautionary Statements : P264-P273-P280-P302+P352-P332+P313-P362+P364-P391-P501

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   2.7673
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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