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Structure of 929022-76-4
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2-Chloro-4-fluoronicotinic acid features a strategically positioned chloro and fluoro substituent on the nicotinic acid scaffold, delivering enhanced electron-withdrawing character and metabolic stability. This configuration supports efficient incorporation into bioactive heterocycles, particularly in medicinal chemistry scaffolds requiring precise electronic tuning and improved pharmacokinetic profiles under standard bench conditions.
2-Chloro-4-fluoronicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-chloro and meta-fluoro substituents provide orthogonal reactivity for palladium-catalyzed couplings and nucleophilic substitutions, while the carboxylic acid group facilitates amide formation and derivatization. The compound exhibits excellent bench stability and is compatible with standard purification protocols, making it ideal for scalable, multi-step syntheses in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: