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CS-W001157 4
Total: USD 88.00

1-(2-Bromo-6-fluorophenyl)ethanone

  • CAS No. 928715-37-1

  • Cat. No. CS-W018884
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(2-Bromo-6-fluorophenyl)ethanone|CS-W018884

Structure of 928715-37-1

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General Information

  • CAS No. 928715-37-1
  • Cat. No. CS-W018884
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrFO
  • Molecular Weight 217.04
  • Synonym(s) 1-(2-bromo-6-fluoro-phenyl)ethanone
  • SMILES CC(C1=C(F)C=CC=C1Br)=O

Description

1-(2-Bromo-6-fluorophenyl)ethanone features a brominated and fluorinated aromatic ring linked to a ketone functionality, enabling direct incorporation into cross-coupling reactions. The electron-deficient aryl moiety enhances reactivity in palladium-catalyzed transformations. This bench-stable compound serves as a key intermediate for pharmaceutical and agrochemical synthesis.

Application

1-(2-Bromo-6-fluorophenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the aryl ring via palladium-catalyzed cross-coupling reactions. Its bromo and fluoro substituents provide orthogonal reactivity for sequential transformations, while the acetyl group offers a handle for further derivatization. The compound exhibits excellent bench stability and is compatible with standard purification methods, facilitating integration into multi-step syntheses of bioactive heterocycles and API intermediates.

Synthesis

  • Route1
    • 1-Bromo-3-fluoro-2-(trimethylsilyl)benzene|CS-0195017
      632324-41-5
    • ~%
    • In-stock
      1-(2-Bromo-6-fluorophenyl)ethanone|CS-W018884
      928715-37-1

    References

    • WO2007/46747 A1, ; Page/Page column 65 ; WO 2007/046747 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.7908
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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