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CS-W001157 4
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4-(4-Fluorobenzyl)piperidine hydrochloride

  • CAS No. 92822-03-2

  • Cat. No. CS-0045397
  • Molecule weight229.72
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(4-Fluorobenzyl)piperidine hydrochloride|CS-0045397

Structure of 92822-03-2

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General Information

  • CAS No. 92822-03-2
  • Cat. No. CS-0045397
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇ClFN
  • Molecular Weight 229.72
  • Synonym(s) Piperidine, 4-[(4-fluorophenyl)methyl]-, hydrochloride
  • SMILES FC1=CC=C(CC2CCNCC2)C=C1.[H]Cl

Description

4-(4-Fluorobenzyl)piperidine hydrochloride delivers a potent, bench-stable scaffold for medicinal chemistry campaigns. The fluorinated aryl group enhances metabolic stability and membrane permeability, while the piperidine core provides a versatile nitrogen handle for conjugation. This salt form ensures excellent solubility in aqueous media and simplifies handling during synthesis and purification workflows.

Application

4-(4-Fluorobenzyl)piperidine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through straightforward functionalization. The piperidine core provides a basic nitrogen for salt formation and derivatization, while the 4-fluorobenzyl group offers enhanced metabolic stability and favorable pharmacokinetic properties. Its crystalline solid form ensures excellent bench stability, ease of handling, and straightforward purification—ideal for high-throughput synthesis and lead optimization campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.7896
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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