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CS-W001157 4
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5-Bromo-8-chloroquinoline

  • CAS No. 927800-41-7

  • Cat. No. CS-0109004
  • Molecule weight242.50
  • Purity≥97%
  • MDL No.MFCD07700234

*For research and further manufacturing use only, not for direct human use.

5-Bromo-8-chloroquinoline|CS-0109004

Structure of 927800-41-7

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General Information

  • CAS No. 927800-41-7
  • Cat. No. CS-0109004
  • Purity ≥97%
  • MDL No. MFCD07700234
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅BrClN
  • Molecular Weight 242.50
  • Synonym(s) None
  • SMILES ClC1=C2N=CC=CC2=C(Br)C=C1

Description

5-Bromo-8-chloroquinoline delivers a sterically constrained, electron-deficient quinoline scaffold ideal for transition metal-catalyzed cross-coupling reactions. The ortho-halogen substitution pattern enables selective functionalization, while the bench-stable nature simplifies handling in synthetic workflows.

Application

5-Bromo-8-chloroquinoline serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. Its complementary halogenation pattern enables selective functionalization via Pd-catalyzed coupling protocols, including Suzuki-Miyaura and Stille reactions. The molecule exhibits good bench stability and facilitates the construction of complex quinoline-based scaffolds found in kinase inhibitors and antimalarial agents.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.6507
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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