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CS-W001157 4
Total: USD 88.00

O-(4-(Trifluoromethyl)phenyl)hydroxylamine

  • CAS No. 92381-17-4

  • Cat. No. CS-0163363
  • Molecule weight177.12
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

O-(4-(Trifluoromethyl)phenyl)hydroxylamine|CS-0163363

Structure of 92381-17-4

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General Information

  • CAS No. 92381-17-4
  • Cat. No. CS-0163363
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₃NO
  • Molecular Weight 177.12
  • Synonym(s) O-[4-(trifluoromethyl)phenyl]hydroxylamine
  • SMILES NOC1=CC=C(C(F)(F)F)C=C1

Description

O-(4-(Trifluoromethyl)phenyl)hydroxylamine features a trifluoromethyl-substituted aryl ring that enhances electron-withdrawal and metabolic stability. This hydroxylamine derivative serves as a key intermediate in the synthesis of bioactive heterocycles, particularly in medicinal chemistry applications involving nitration or diazotization pathways.

Application

O-(4-(Trifluoromethyl)phenyl)hydroxylamine serves as a versatile building block for the synthesis of trifluoromethyl-substituted heterocycles and pharmaceutical intermediates. Its stability under standard reaction conditions enables reliable use in nucleophilic substitution, coupling, and electrophilic aromatic substitution reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. Functional group tolerance facilitates downstream derivatization without protection.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H302-H312-H315-H318-H332-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.9579
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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