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CS-W001157 4
Total: USD 88.00

1-(Difluoromethoxy)-2-iodobenzene

  • CAS No. 920981-12-0

  • Cat. No. CS-W021254
  • Purity≥95%
  • MDL No.MFCD09749662

*For research and further manufacturing use only, not for direct human use.

1-(Difluoromethoxy)-2-iodobenzene|CS-W021254

Structure of 920981-12-0

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General Information

  • CAS No. 920981-12-0
  • Cat. No. CS-W021254
  • Purity ≥95%
  • MDL No. MFCD09749662
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂IO
  • Molecular Weight 270.02
  • Synonym(s) 1-Difluoromethoxy-2-iodobenzene
  • SMILES IC1=CC=CC=C1OC(F)F

Description

1-(Difluoromethoxy)-2-iodobenzene features a strategically positioned iodine atom and a difluoromethoxy group on adjacent aromatic ring positions, enabling efficient cross-coupling reactions. This electron-deficient aryl iodide delivers high reactivity in palladium-catalyzed transformations, facilitating rapid access to complex fluorinated biaryls under mild conditions.

Application

1-(Difluoromethoxy)-2-iodobenzene serves as a versatile aryl iodide building block for palladium-catalyzed cross-coupling reactions, including Suzuki, Stille, and Negishi couplings. The difluoromethoxy group imparts enhanced metabolic stability and modulates electronic properties, making this compound valuable in medicinal chemistry. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of complex biaryl architectures.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.8926
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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