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CS-W001157 4
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5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

  • CAS No. 920978-94-5

  • Cat. No. CS-0004680
  • Purity≥95%
  • MDL No.MFCD11518911

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid|CS-0004680

Structure of 920978-94-5

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General Information

  • CAS No. 920978-94-5
  • Cat. No. CS-0004680
  • Purity ≥95%
  • MDL No. MFCD11518911
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅FN₂O₂
  • Molecular Weight 180.14
  • Synonym(s) 5-Fluoro-7-azaindole-2-carboxylic acid
  • SMILES O=C(O)C1=CC2=CC(F)=CN=C2N1

Description

5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid features a fluorinated heterocyclic core with a carboxylic acid group at the 2-position, enabling direct incorporation into bioactive molecules. The electron-deficient pyrrolopyridine scaffold supports efficient coupling reactions and enhances metabolic stability in pharmaceutical applications.

Application

5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via standard coupling and functionalization reactions. Its well-defined reactivity profile, combined with bench-stable crystalline form and compatibility with common synthetic transformations, facilitates efficient access to diverse scaffolds for drug discovery applications.

Synthesis

  • Route1
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    • Pyruvic acid, ≥97%|CS-1268663
      127-17-3
    • ~%
    • In-stock
      5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid|CS-0004680
      920978-94-5

    References

    • US2008/125459 A1, ; Page/Page column 13 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.4002
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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