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tert-Butyl (5-aminopyrazin-2-yl)carbamate

  • CAS No. 920313-67-3

  • Cat. No. CS-0019366
  • Purity≥95%
  • MDL No.MFCD22421596

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (5-aminopyrazin-2-yl)carbamate|CS-0019366

Structure of 920313-67-3

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General Information

  • CAS No. 920313-67-3
  • Cat. No. CS-0019366
  • Purity ≥95%
  • MDL No. MFCD22421596
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄N₄O₂
  • Molecular Weight 210.23
  • Synonym(s) tert-Butyl (5-aminopyrazin-2-yl)
  • SMILES O=C(OC(C)(C)C)NC1=NC=C(N)N=C1

Description

tert-Butyl (5-aminopyrazin-2-yl)carbamate features a pyrazine core with orthogonal functional handles: a protected amine at the 5-position and a carbamate group enabling facile deprotection. This bench-stable derivative serves as a key intermediate in the synthesis of bioactive heterocycles, particularly in medicinal chemistry campaigns targeting kinase inhibitors and antitumor agents.

Application

tert-Butyl (5-aminopyrazin-2-yl)carbamate serves as a versatile pyrazine-based building block for medicinal chemistry and process development. The protected amine enables orthogonal functionalization in multistep syntheses, while the pyrazin-2-yl core supports diverse coupling reactions and heterocycle elaboration. Bench-stable and easily purified, it functions effectively in standard amide bond formation, metal-catalyzed cross-couplings, and late-stage derivatization workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   90.13
  • LogP   1.4058
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   1

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