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5-Cyclopropylpyrazin-2-amine

  • CAS No. 920313-51-5

  • Cat. No. CS-0157921
  • Purity≥95%
  • MDL No.MFCD12032675

*For research and further manufacturing use only, not for direct human use.

5-Cyclopropylpyrazin-2-amine|CS-0157921

Structure of 920313-51-5

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General Information

  • CAS No. 920313-51-5
  • Cat. No. CS-0157921
  • Purity ≥95%
  • MDL No. MFCD12032675
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉N₃
  • Molecular Weight 135.17
  • Synonym(s) 5-Cyclopropyl-pyrazin-2-ylamine
  • SMILES C1(CC1)C=2N=CC(=NC2)N

Description

5-Cyclopropylpyrazin-2-amine features a cyclopropyl group at the 5-position of a pyrazine core, enhancing lipophilicity and metabolic stability. This electron-deficient heterocycle serves as a key scaffold in kinase inhibitor design, offering improved membrane permeability and target engagement.

Application

5-Cyclopropylpyrazin-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyrazine-based scaffolds. Its cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, while the primary amine facilitates downstream functionalization via coupling reactions. The compound exhibits good bench stability and is compatible with standard synthetic workflows, including amide bond formation and Suzuki-Miyaura coupling, making it valuable for the development of API candidates and targeted library synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.9362
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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