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CS-W001157 4
Total: USD 88.00

5-(4-Pyridinyl)-1H-pyrazol-3-amine

  • CAS No. 91912-53-7

  • Cat. No. CS-0208112
  • Purity≥98%
  • MDL No.MFCD06738752

*For research and further manufacturing use only, not for direct human use.

5-(4-Pyridinyl)-1H-pyrazol-3-amine|CS-0208112

Structure of 91912-53-7

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General Information

  • CAS No. 91912-53-7
  • Cat. No. CS-0208112
  • Purity ≥98%
  • MDL No. MFCD06738752
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₄
  • Molecular Weight 160.18
  • Synonym(s) 3-(pyridin-4-yl)-1H-pyrazol-5-amine
  • SMILES NC1=NNC(C2=CC=NC=C2)=C1

Description

5-(4-Pyridinyl)-1H-pyrazol-3-amine features a conjugated pyrazole core linked to a pyridine moiety, enabling robust π-stacking and hydrogen bonding interactions. This electron-rich heterocycle integrates readily into pharmaceutical scaffolds, offering enhanced solubility and metabolic stability in bioactive molecule design.

Application

5-(4-Pyridinyl)-1H-pyrazol-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through standard coupling reactions. Its pyridyl and primary amine functionalities offer orthogonal reactivity for further derivatization, while its bench-stable solid form facilitates handling and purification in multi-step syntheses.

Synthesis

  • Route1
    • In-stock
      Isonicotinic acid, ethyl ester|CS-W020597
      1570-45-2
    • null|null
      75-05-8
    • ~25%
    • In-stock
      5-(4-Pyridinyl)-1H-pyrazol-3-amine|CS-0208112
      91912-53-7

    References

    • US2011/294781 A1, ; Page/Page column 45 ;
  • Route2
    • null|null
      569656-00-4
    • ~15%
    • In-stock
      5-(4-Pyridinyl)-1H-pyrazol-3-amine|CS-0208112
      91912-53-7

    References

    • US2005/113283 A1, ;
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 24 p. 6890 - 6892

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   67.59
  • LogP   1.0539
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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