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CS-W001157 4
Total: USD 88.00

2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine

  • CAS No. 918538-05-3

  • Cat. No. CS-D0127
  • Purity≥97%
  • MDL No.MFCD11044885
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine|CS-D0127

Structure of 918538-05-3

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Description

2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine is a chlorinated heterocyclic scaffold featuring a fused triazine core with strategic substitution at the 2- and 4-positions. This electron-deficient architecture enables efficient coupling in cross-coupling transformations and serves as a key building block in medicinal chemistry for targeted kinase inhibition. The molecule exhibits enhanced stability under standard conditions and facilitates direct functionalization at the pyrrole ring.

Application

2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine serves as a versatile building block in medicinal chemistry, enabling efficient construction of nitrogen-rich heterocyclic scaffolds. The dichloro substituents facilitate direct nucleophilic substitution reactions under mild conditions, allowing rapid diversification at C2 and C4 positions. Its stability under standard reaction conditions and compatibility with common functional groups make it ideal for parallel synthesis campaigns targeting kinase inhibitors and other bioactive compounds.

General Information

  • CAS No. 918538-05-3
  • Cat. No. CS-D0127
  • Purity ≥97%
  • MDL No. MFCD11044885
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃Cl₂N₃
  • Molecular Weight 188.01
  • Synonym(s) 4-Dichloropyrrolo[1
  • SMILES ClC1=NC(Cl)=NN2C1=CC=C2

Computational Chemistry Data

  • TPSA   30.19
  • LogP   2.0361
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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