4-Chlorofuro[2,3-d]pyrimidine

Name: 4-Chlorofuro[2,3-d]pyrimidine
Brand: ChemScene
Availability: InStock
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CAS No. 918340-51-9
Cat. No. CS-0050888
Purity≥95%
MDL No.MFCD09834941

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chlorofuro[2,3-d]pyrimidine|CS-0050888

Structure of 918340-51-9

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General Information

CAS No. 918340-51-9
Cat. No. CS-0050888
Purity ≥95%
MDL No. MFCD09834941
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClN₂O
Molecular Weight 154.55
Synonym(s) Furo[2,3-d]pyrimidine, 4-chloro-
SMILES ClC1=C2C=COC2=NC=N1

Description

4-Chlorofuro[2,3-d]pyrimidine is a heterocyclic building block featuring a fused furo[2,3-d]pyrimidine core with a chlorine substituent at the 4-position. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive nucleosides and kinase inhibitors. The molecule exhibits excellent stability under standard bench conditions and integrates readily into complex molecular architectures.

Application

4-Chlorofuro[2,3-d]pyrimidine serves as a versatile building block for the synthesis of bioactive heterocycles, particularly in medicinal chemistry and agrochemical development. Its electrophilic chlorine at the 4-position enables efficient nucleophilic substitution reactions, facilitating the installation of diverse side chains. The fused furan-pyrimidine core provides structural rigidity and favorable electronic properties, enhancing binding affinity in target-directed scaffolds. Bench-stable and compatible with standard reaction conditions, it functions reliably in multi-step syntheses requiring functional group tolerance and predictable reactivity.

Synthesis

Route1
- 186454-70-6
- ~40%
- In-stock
  
  918340-51-9
References
- YALE UNIVERSITY Patent: WO2007/38387 A2, 2007 ; Location in patent: Page/Page column 80-81 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.92
LogP 1.8762
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Furan compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4-Chlorofuro[2,3-d]pyrimidine

CAS No. 918340-51-9

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