3-Bromo-6-chloro-2,4-dimethylpyridine

Name: 3-Bromo-6-chloro-2,4-dimethylpyridine
Brand: ChemScene
Availability: InStock
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CAS No. 918145-29-6
Cat. No. CS-0019365
Purity≥96%
MDL No.MFCD20486518

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Bromo-6-chloro-2,4-dimethylpyridine|CS-0019365

Structure of 918145-29-6

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General Information

CAS No. 918145-29-6
Cat. No. CS-0019365
Purity ≥96%
MDL No. MFCD20486518
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇BrClN
Molecular Weight 220.49
Synonym(s) 3-Bromo-2,4-dimethyl-6-chloropyridine; 5-broMo-2-chloro-4,6-diMethylpyridine
SMILES CC1=C(Br)C(C)=NC(Cl)=C1

Description

3-Bromo-6-chloro-2,4-dimethylpyridine features a sterically hindered pyridine core with complementary halogen handles, enabling selective cross-coupling reactions. The ortho-methyl groups enhance stability while the bromo and chloro substituents offer orthogonal reactivity for sequential functionalization. This bench-stable derivative serves as a key building block in medicinal chemistry and agrochemical synthesis.

Application

3-Bromo-6-chloro-2,4-dimethylpyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The ortho-methyl groups stabilize the pyridine core and enhance regioselectivity in electrophilic substitutions. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient construction of substituted pyridine scaffolds relevant to pharmaceutical intermediates.

Synthesis

Route1
- In-stock
  
  89856-44-0
- ~52%
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  918145-29-6
References
- Crawford, Jason B.; Chen, Gang; Carpenter, Bryon; Wilson, Trevor; Ji, Jenny; Skerlj, Renato T.; Bridger, Gary J. Organic Process Research and Development, 2012 , vol. 16, # 1 p. 109 - 116

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 12.89
LogP 3.11434
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Bromo-6-chloro-2,4-dimethylpyridine

CAS No. 918145-29-6

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