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CS-W001157 4
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1-(5-Bromopyridin-2-yl)-2,2,2-trifluoroethanol

  • CAS No. 917397-92-3

  • Cat. No. CS-0060448
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(5-Bromopyridin-2-yl)-2,2,2-trifluoroethanol|CS-0060448

Structure of 917397-92-3

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General Information

  • CAS No. 917397-92-3
  • Cat. No. CS-0060448
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrF₃NO
  • Molecular Weight 256.02
  • Synonym(s) None
  • SMILES C1=CC(=NC=C1Br)C(C(F)(F)F)O

Description

1-(5-Bromopyridin-2-yl)-2,2,2-trifluoroethanol features a brominated pyridine moiety paired with a trifluoromethyl-bearing alcohol, enabling direct incorporation into cross-coupling and functionalization workflows. The electron-deficient pyridine ring enhances reactivity in palladium-catalyzed transformations, while the trifluoromethyl group imparts enhanced metabolic stability and lipophilicity. This compound serves as a valuable synthon for bioactive molecule synthesis.

Application

1-(5-Bromopyridin-2-yl)-2,2,2-trifluoroethanol serves as a versatile building block for constructing brominated heterocyclic scaffolds in medicinal chemistry and materials science. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the bromopyridine moiety enables subsequent cross-coupling reactions such as Suzuki-Miyaura and Stille coupling. Its bench-stable crystalline form facilitates handling and purification, making it ideal for scalable synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.4398
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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