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2-Bromo-6-chloropyrazine

  • CAS No. 916791-07-6

  • Cat. No. CS-0129020
  • Purity≥98%
  • MDL No.MFCD08752648

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-chloropyrazine|CS-0129020

Structure of 916791-07-6

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General Information

  • CAS No. 916791-07-6
  • Cat. No. CS-0129020
  • Purity ≥98%
  • MDL No. MFCD08752648
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂BrClN₂
  • Molecular Weight 193.43
  • Synonym(s) 2-bromanyl-6-chloranyl-pyrazine
  • SMILES ClC1=CN=CC(Br)=N1

Description

2-Bromo-6-chloropyrazine is a heterocyclic halogenated pyrazine featuring bromine at the 2-position and chlorine at the 6-position, enabling selective cross-coupling reactions. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and functional materials, offering enhanced reactivity in palladium-catalyzed transformations under standard conditions.

Application

2-Bromo-6-chloropyrazine serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates efficient C–C bond formation under standard Suzuki or Stille conditions, while the chloro substituent offers enhanced stability and selective functionalization. This compound exhibits bench stability, ease of handling, and compatibility with diverse reaction conditions, making it ideal for constructing complex pyrazine-based scaffolds in high-throughput screening campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.8925
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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