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CS-W001157 4
Total: USD 88.00

3,4-Dihydro-2H-1,4-benzoxazin-6-ylmethanol

  • CAS No. 915160-96-2

  • Cat. No. CS-0035700
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,4-Dihydro-2H-1,4-benzoxazin-6-ylmethanol|CS-0035700

Structure of 915160-96-2

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General Information

  • CAS No. 915160-96-2
  • Cat. No. CS-0035700
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₂
  • Molecular Weight 165.19
  • Synonym(s) 3,4-Dihydro-2H-1,4-Benzoxazin-6-Ylmethanol(WX640269)
  • SMILES C1=C(C=C2C(=C1)OCCN2)CO

Description

3,4-Dihydro-2H-1,4-benzoxazin-6-ylmethanol features a fused heterocyclic core with a pendant hydroxymethyl group, enabling direct functionalization in synthetic sequences. This bench-stable scaffold integrates readily into bioactive molecule frameworks, offering enhanced solubility and metabolic stability in medicinal chemistry applications.

Application

3,4-Dihydro-2H-1,4-benzoxazin-6-ylmethanol serves as a versatile scaffold for heterocyclic synthesis, enabling efficient access to bioactive analogs through functional group manipulation. The pendant hydroxymethyl moiety facilitates derivatization via etherification, oxidation, or coupling reactions, while the benzoxazine core exhibits favorable bench stability and compatibility with standard reaction conditions. Functions effectively in medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors.

Synthesis

  • Route1

    References

    • WO2003/87098 A1, ; Page/Page column 54-55 ;
  • Route2

    References

    • US2007/10670 A1, ; Page/Page column 97 ;
  • Route3
    • In-stock
      2-Amino-4-(hydroxymethyl)phenol|CS-0197260
      52820-13-0
    • null|null
      106-93-4
    • ~%
    • In-stock
      3,4-Dihydro-2H-1,4-benzoxazin-6-ylmethanol|CS-0035700
      915160-96-2

    References

    • Tetrahedron Letters, , vol. 47, # 44 p. 7823 - 7826

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.49
  • LogP   0.9832
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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