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(S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran

  • CAS No. 915095-89-5

  • Cat. No. CS-0015036
  • Molecule weight367.67
  • Purity≥97%
  • MDL No.MFCD27920793

*For research and further manufacturing use only, not for direct human use.

(S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran|CS-0015036

Structure of 915095-89-5

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General Information

  • CAS No. 915095-89-5
  • Cat. No. CS-0015036
  • Purity ≥97%
  • MDL No. MFCD27920793
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₆BrClO₂
  • Molecular Weight 367.67
  • Synonym(s) None
  • SMILES ClC1=CC=C(Br)C=C1CC2=CC=C(O[C@@H]3COCC3)C=C2

Description

(S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran is a chiral tetrahydrofuran derivative featuring a bromochlorobenzyl substituent. This scaffold integrates a rigid, electron-deficient aryl group with a stereodefined ether linkage, enabling precise spatial orientation in asymmetric synthesis. The molecule exhibits bench-stable handling and compatibility with standard coupling protocols.

Application

(S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran serves as a versatile chiral building block for medicinal chemistry campaigns, enabling efficient construction of bioactive heterocycles. Its pendant phenoxy-tetrahydrofuran motif exhibits excellent stability under standard synthetic conditions and facilitates orthogonal functionalization. The molecule's defined stereochemistry at the tetrahydrofuran ring supports predictable reaction outcomes in downstream coupling and cyclization processes, making it well-suited for parallel synthesis and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   4.861
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

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